Bill and Jane are giddy with excitement for their vacation to Spain to begin, pre-Covid-19, of course. They each grab a coffee from the airport stand as they anxiously await their flight. Aboard the plane, they enjoy their snacks with a side of afternoon coffee to give them a boost before they land. After finally arriving in Spain from a long flight, they checked into their hotel in the evening before heading out for a night on the town.
They had a great dinner at a highly suggested Spanish restaurant accompanied by several glasses of the house sangria and a most delicious caramel flan. The next day, they overslept. Though in a frenzy, they managed to rush out of the hotel room and make it to the bus just in time for a day of sight-seeing. Making up for their skipped breakfast, they had lunch at a Tapas bar with a little more sangria. In this case..when in Spain. However, as the day progressed into the evening, they both started to feel terrible. They had severe headaches, muscle discomfort, anxiety, and slight depression. Can you guess what is wrong with them?
They both overdid the sangria and should perhaps switch to cranberry juice
They’ve bought too many souvenirs and have grown weary
They are suffering from adenosine receptor toxicity
All of the above
SCROLL FOR ANSWER
The correct answer is #3. However, #4 could have its own case.
Bill and Jane are regular coffee drinkers. They hadn’t had any coffee for over 24 hours and were experiencing the classic symptoms of caffeine withdrawal! Here is how it works:
Coffee triggers the brain by stimulating the chemicals responsible for many of the pleasant effects of caffeine, such as mood elevation and increased alertness. The stimulating effect of coffee comes from the way it interacts with a chemical called adenosine. Adenosine normally binds with a receptor meant to pair specifically together with the intention of causing a deceleration in brain activity, leading to a sleepy feeling. Caffeine, having a similar structure, binds with the adenosine receptors instead. However, as we know, caffeine doesn’t slow your brain in a normal way. When your body senses that the adenosine is not having its calming effect, it increases those receptors. When the caffeine stops, all these receptors capture the adenosine and result in dilated blood vessels in the brain. This is what leads to severe migraine-like headaches and many of the symptoms that Bill and Jane were experiencing.
The treatment is simple: four large cups of Plantation Gourmet Coffee or 2 double espressos as soon as possible.